Cancer Treatments and Prevention PowerPoint Presentation free Biology Diagrams Embryonic stem cells (ESCs) have an unusual cell cycle structure with a short G1 phase and with the largest proportion of cells in the S phase. During differentiation, the ESC cycle is readily remodeled and a prominent G1 phase is established. Recently, prolongation
The cell-cycle state of stem cells determines cell fate propensity. Cell 155 , 135-147 (2013). Article CAS PubMed PubMed Central Google Scholar
Brief Report: Cell Cycle Dynamics of Human Pluripotent Stem Cells ... Biology Diagrams
The unusual cell cycle properties of ESCs change upon dissolution of pluripotency, when stem cells undergo cell fate specification and differentiate into different lineages 16,. During this process, cell division length increases, mainly due to an expanded G1 phase 16 , 24 , 28 , 34 , 43 , 58 .
Stem cell self-renewal is intrinsically associated with cell cycle control. However, the precise mechanisms coordinating cell fate choices and cell cycle remain to be fully uncovered. Now in Cell, Gonzales et al. (2015) and colleagues demonstrate that factors controlling the G2/M phase are necessary to block pluripotency upon induction of differentiation. (a) Stem cells exposed to cell fate specification cues differentiate as an asynchronous wave.(b) The asynchronous differentiation program can be accounted for by the activation of developmental genes in G1-phase of the cell cycle. Cells in G1 respond rapidly to differentiation cues whereas cells in S-, G2-and M-phase experience a delay, indicated by the kinetics of transcriptional activation. Cyclins, cyclin-dependent kinases and other components of the core cell cycle machinery drive cell division. Growing evidence indicates that this machinery operates in a distinct fashion in some mammalian stem cell types, such as pluripotent embryonic stem cells. In this Review, we discuss our curre โฆ
renewal of Embryonic Stem Cells: Cell Cycle Regulation Biology Diagrams
The cell-cycle state of stem cells determines cell fate propensity. Cell 155, 135-47 (2013). Article CAS Google Scholar Singh, A. M. et al. Cell-Cycle Control of Developmentally Regulated
