Cell cycle Biology Diagrams Pluripotency is also linked with cell-cycle regulation because studies in mouse ESCs (mESCs) have shown that their pluripotent status is associated with a specific cell-cycle profile characterized by a shortened G1 phase and the lack of G1 checkpoint regulation (Coronado et al., 2013; Savatier et al., 1996).In conventional cells, cyclin D1-3 are expressed in G1 phase and control the activity
Cell cycle represents not only a tightly orchestrated mechanism of cell replication and cell division but it also plays an important role in regulation of cell fate decision. Particularly in the context of pluripotent stem cells or multipotent progenitor cells, regulation of cell fate decision is of โฆ
The cell cycle in stem cell proliferation, pluripotency and ... Biology Diagrams
Embryonic stem cells (ESCs) have an unusual cell cycle structure with a short G1 phase and with the largest proportion of cells in the S phase. During differentiation, the ESC cycle is readily remodeled and a prominent G1 phase is established. Recently, prolongation Human embryonic and pluripotent stem cells are known to have minimal regulatory control across phases of the cell cycle and be refractory toward growth inhibitory signals. As a result, oscillation of gene expression across phases of the cell cycle is modest in hPSCs 25 - 27 .
Stem cell self-renewal is intrinsically associated with cell cycle control. However, the precise mechanisms coordinating cell fate choices and cell cycle remain to be fully uncovered. Now in Cell, Gonzales et al. (2015) and colleagues demonstrate that factors controlling the G2/M phase are necessary to block pluripotency upon induction of differentiation. The unusual cell cycle properties of ESCs change upon dissolution of pluripotency, when stem cells undergo cell fate specification and differentiate into different lineages 16,. During this process, cell division length increases, mainly due to an expanded G1 phase 16 , 24 , 28 , 34 , 43 , 58 . The cell-cycle state of stem cells determines cell fate propensity. Cell 155, 135-47 (2013). Article CAS Google Scholar Singh, A. M. et al. Cell-Cycle Control of Developmentally Regulated
The cell cycle in stem cell proliferation, pluripotency and ... Biology Diagrams
(a) Stem cells exposed to cell fate specification cues differentiate as an asynchronous wave.(b) The asynchronous differentiation program can be accounted for by the activation of developmental genes in G1-phase of the cell cycle. Cells in G1 respond rapidly to differentiation cues whereas cells in S-, G2-and M-phase experience a delay, indicated by the kinetics of transcriptional activation. The cell-cycle state of stem cells determines cell fate propensity. Cell 155 , 135-147 (2013). Article CAS PubMed PubMed Central Google Scholar Cyclins, cyclin-dependent kinases and other components of the core cell cycle machinery drive cell division. Growing evidence indicates that this machinery operates in a distinct fashion in some mammalian stem cell types, such as pluripotent embryonic stem cells. In this Review, we discuss our curre โฆ
