Structural model of motorized spindle Biology Diagrams Principles and dynamics of spindle assembly checkpoint signalling Spindle pole OFF ON MCC MCC APC/CCDC20 APC/CCDC20 Aurora B Anaphase onset Securin Cyclin B Separase CDK1 APC/CCDCc20 Accurate chromosome segregation and spindle positioning during cell division are critical for genomic stability, with these processes regulated by the spindle assembly checkpoint (SAC) and spindle positioning checkpoint (SPOC) [1], [2].The SAC ensures that chromosomes are properly attached to the spindle before anaphase, preventing premature separation and aneuploidy [3], [4], while the SPOC The transmission of a complete set of chromosomes to daughter cells during cell division is vital for development and tissue homeostasis. The spindle assembly checkpoint (SAC) ensures correct segregation by informing the cell cycle machinery of potential errors in the interactions of chromosomes with spindle microtubules prior to anaphase.
Current Biology Review The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics Andrea Musacchio1,2 1Department of Mechanistic Cell Biology, Max Planck Institute of Molecular Physiology, Dortmund, Germany 2Centre for Medical Biotechnology, Faculty of Biology, University Duisburg-Essen, Essen, Germany Correspondence: andrea.musacchio@mpi-dortmund.mpg.de Dynamics of spindle assembly and position checkpoints: Integrating molecular mechanisms with computational models Comput Struct Biotechnol J. 2025 Jan 10 including bistable switches driving spindle assembly checkpoint (SAC) activation, spatial organization principles underlying spindle position checkpoint (SPOC) signaling, and critical
Dynamics of spindle assembly and position checkpoints: Integrating ... Biology Diagrams
NuMA regulates mitotic spindle assembly, structural dynamics and function via phase separation Article Open access 09 December 2021. Surveillance of cohesin-supported chromosome structure controls During mitosis and meiosis, the spindle assembly checkpoint acts to maintain genome stability by delaying cell division until accurate chromosome segregation can be guaranteed. Accuracy requires that chromosomes become correctly attached to the microtubule spindle apparatus via their kinetochores. When not correctly attached to the spindle, kinetochores activate the spindle assembly checkpoint
Before the cell can proceed further, to anaphase, a checkpoint mechanism, the spindle assembly checkpoint (SAC) determines that each member of a chromatid pair is correctly attached to the opposite spindle poles (Sear and Howard 2006; Musacchio and Salmon 2007). This is a tension-sensing mechanism: correct attachments are in a state of tension Principles and dynamics of spindle assembly checkpoint signalling Article 24 March 2023. Introduction. The spindle, first described in the 1880s 1 by The spindle assembly checkpoint (SAC, also known as mitotic or metaphase checkpoint) is a feedback-control system that operates during cell division in eukaryotic cells 1, 2, 3.The SAC monitors chromosome bi-orientation on the mitotic spindle, and as long as improperly attached chromosomes remain, it halts cells in mitosis and precludes passage into the final phases of cell division (Figure 1).
