THE CELL CYCLE AND CANCER PowerPoint Presentation free download Biology Diagrams Cancer stem cells and the cell cycle: targeting the drive behind breast cancer. Cancer stem cells and the cell cycle: targeting the drive behind breast cancer Expert Rev Anticancer Ther. 2009 Mar;9(3):275-9. doi: 10.1586/14737140.9.3.275. Authors Marco A Cancer is a group of diseases in which cells divide continuously and excessively. Cell division is tightly regulated by multiple evolutionarily conserved cell cycle control mechanisms, to ensure The cell-cycle state of stem cells determines cell fate propensity. Cell 155 , 135-147 (2013). Article CAS PubMed PubMed Central Google Scholar
Cell cycle regulation depends on phase-specific transcriptions of cell cycle genes. The alterations of cell cycle genes can predispose normal cells to have a cancerous phenotype. Indeed, several mechanisms underlying the deregulation of the cell cycle have been identified in different types of cancer. In addition to the properties of self-renewal and multipotency, cancer stem cells share the characteristics of their distinct cell cycle status with somatic stem cells. Cancer stem cells (CSCs) are maintained in a quiescent state with this characteristic conferring resistance to anticancer therapies that target dividing cells. Elucidation of
TET1 regulates stem cell properties and cell cycle of Cancer stem cells ... Biology Diagrams
Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor heterogeneity. The core cell cycle machinery operating in the cell nucleus orchestrates cell division. The key components of this machinery are proteins called cyclins that bind, activate and provide substrate specificity to their associated catalytic partners, the cyclin-dependent kinases (CDKs) 1-4.Cell cycle progression can be divided into four phases: gap 1 (G1), DNA synthesis (S), gap 2 (G2) and
Pluripotency is also linked with cell-cycle regulation because studies in mouse ESCs (mESCs) have shown that their pluripotent status is associated with a specific cell-cycle profile characterized by a shortened G1 phase and the lack of G1 checkpoint regulation (Coronado et al., 2013; Savatier et al., 1996).In conventional cells, cyclin D1-3 are expressed in G1 phase and control the activity The role of cancer stem cells in metastasis, recurrence, and resistance to conventional therapies is significant. Addressing these cells could potentially decrease cancer reoccurrences and mortality rates. TET1, a crucial gene involved in stem cell self-renewal and potency, may also play a part in cancer stem cells, which warrants further research.
